NEUROSCIENCES AND NEUROANAESTHESIA Apoptotic neurodegeneration and spatial memory are not affected by sedative and anaesthetics doses of ketamine/medetomidine combinations in adult mice
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چکیده
Editor’s key points † The combined effect of ketamine and medetomidine on cognition and apoptosis was studied in mice. † No differences were seen between groups in terms of spatial memory or apoptosis. † Hyperlocomotive activity in mice receiving ketamine was attenuated by medetomidine. † Co-administration of ketamine and medetomidine may be clinically useful. Background. Ketamine is increasingly popular in clinical practice and its combination with a2-agonists can provide good anaesthetic stability. Little is known about the effects of this combination in the brain. Therefore, we investigated the effects of different concentrations of ketamine combined with medetomidine on cognition and its potential apoptotic neurodegenerative effect in adult mice.
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